Microneedles are emerging drug delivery methods for painless treatment. The current\nstudy tested dissolving microneedles containing lidocaine (Li-DMN) for use in local anesthesia.\nAn Li-DMN patch was fabricated by centrifugal lithography with carboxymethyl cellulose as a\nstructural polymer and assessed for physical properties by optical microscopy and a fracture force\nanalyzer. The biocompatibility was evaluated by a histology section in vitro and by ear thickness\nin vivo. The efficacy of the Li-DMN patch was assessed by electrophysiological recordings in primary\ncultured sensory neurons in vitro and a von Frey test on ratsâ?? hind paws in vivo. The physical\nproperties of the microneedle showed enough rigidity for transdermal penetration. The maximal\ncapacity of lidocaine-HCl in the Li-DMN patch was 331.20...................
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